Heparin

(11 posts)(5 voices)
  1. Anyone here been given Heparin or something similar during your cycle? If so, when and how often and how much were you given?

    Thanks!

  2. Two shots per day...timing like the lupron. I started just after retrieval, then the RE's would like you to stay on them for quite a while when you get your bfp...like months. I didn't get the bfp, but I did get a chemical which was better than the 2 bfn cycles before at least. I think the heparin did help, the embies just weren't the best quality. Now on to DE. I will take heparin again for this cycle.
    I won't lie, the shots cause lots of bruising and tenderness in the area you have been injecting. In fact, the bruising stayed for 2 months after I discontinued the shots. The actual injection can sting if you go too fast, but go slow, and it won't hurt.

    Lots of luck!

  3. Same as tjs re timing and discomfort , but only once a day.

    Dana

  4. I was hoping for a hail mary type of shot just before or after transfer. Maybe not. ;-} Thanks for your responses. I take it you were both diagnosed with a blood clotting issue?

  5. That would be great if we could do that, but it seems to be much more involved. You even have to get on board with a hematologist once you get the bfp to monitor your levels.
    I had the autoimmune labs ran (after the 2nd failed ivf), and they came back showing: anticardiolipin antibodies were elevated, as well as Anti-beta-2-glycoprotein was also elevated. This means I am at increased risk for clotting. "Those lab abnormalities can inhibit the embryo from implanting, as well as cause miscarriage, which is they start you on the heparin. This medication thins the blood, thus decreasing the likelihood of clotting." That's from my nurse's email...

  6. TJS - I also had elevated anticardiolipin antibodies, but I was only at 15 at one test and 13 at another... that makes me elevated, but I am "indeterminate" for a problem, not high enough to be a real problem. I even went to a hemotologist who said that it wasn't high enough to be a problem, but I've had enough m/c (both natural and DE IVF) to wonder if that may be my problem. Nothing else came up in my BW.

    Sorry you have to go through all of those shots. Blech. Sounds like a fresh level of hell!

    That would be great if we could do that, but it seems to be much more involved. You even have to get on board with a hematologist once you get the bfp to monitor your levels. I had the autoimmune labs ran (after the 2nd failed ivf), and they came back showing: anticardiolipin antibodies were elevated, as well as Anti-beta-2-glycoprotein was also elevated. This means I am at increased risk for clotting. "Those lab abnormalities can inhibit the embryo from implanting, as well as cause miscarriage, which is they start you on the heparin. This medication thins the blood, thus decreasing the likelihood of clotting." That's from my nurse's email...

  7. But...like I said, I really think it helps! I got a chem. with two subpar morula/blasts the last time. I wish I would've had that knowledge the 2nd ivf when we produced 2 really nice blasts. Hindsight...
    Hope it does the trick for you!

  8. I'm DE, so the problem for me is more implantation problems.

  9. Prior to DE IVF in Nov, I found out that I'm positive for MTHFR (homozygous). I was put on baby aspirin. On transfer day, I was switched to daily Framin 2500 IU (0.2ml) and will be on it until 2nd trimester (or longer). Blood monitoring is not needed. I'm currently 9 wks pregnant. I'd prefer BA over the shots...

    I wish we had discovered this condition before my previous (3 OE IVF) cycles. It could have been the cause of my early miscarriages. I've tested negative for everything else.

  10. I found out from the doctor who did my transfer yesterday that 30% of the population has MTHFR. Crazy, huh?

  11. But you have to have both MTFR mutations for it to be clinically significant, which I'm guessing equals far less than the 30% quoted.

    FWIW, my MFM feels that lovenox/heparin are far overused in pregnancy now - there isn't a lot of evidence that the clotting disorders being picked up are really causing pregnancy problems or that the treatment solves them. And being treated with a blood thinner is not a benign intervention. There's apparently a large study going on now - I don't know when the results will be in, but it should be interesting when it comes out.

    However, daily baby aspirin has been shown to have a positive effect on pregnancy rates.

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